CasNo： 120511-73-1
Molecular Formula： C17H19N5
Appearance： crystalline solid
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Anastrozole is a nonsteroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer. Anastrozole has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
![2-[3-bromomethyl-5-(cyanodimethylmethyl)phenyl]-2-methylpropanenitrile](/upload/2023/8/f99455c5-a6f1-4c70-891d-a24a6acdbccb.png)
2-[3-bromomethyl-5-(cyanodimethylmethyl)phenyl]-2-methylpropanenitrile
sodium triazole
3,5-bis(2-cyanoprop-2-yl)toluene
α,α,α',α'-tetramethyl-5-(4H-1,2,4-triazol-4ylmethyl)-1,3-benzene-diacetonitrile
anastrozol
| Conditions | Yield |
|---|---|
|
In
N,N-dimethyl-formamide;
at -10 - -5 ℃;
for 0.75h;
Product distribution / selectivity;
|
3,5-bis(2-cyanoprop-2-yl)toluene
α,α,α',α'-tetramethyl-5-(4H-1,2,4-triazol-4ylmethyl)-1,3-benzene-diacetonitrile
anastrozol
| Conditions | Yield |
|---|---|
|
In
di-isopropyl ether; toluene;
at 30 - 35 ℃;
for 0.5 - 2h;
Purification / work up;
Heating / reflux;
|
The CAS number of Anastrozole is 120511-73-1.
More information of Anastrozole 120511-73-1 are:
|
CAS Number |
120511-73-1 |
|
Density |
1.085 g/cm3 |
|
Melting Point |
81 - 82 °C |
|
Boiling Point |
469.718 °C at 760 mmHg |
|
Flash Point |
237.877 °C |
|
Refractive Index |
1.791 |
|
HS CODE |
29339980 |
|
PSA |
78.29000 |
|
LogP |
2.92876 |
|
Pka |
2.62±0.10(Predicted) |
Synonyms for Anastrozole 120511-73-1:10-Methoxy-5H-dibenz[b,f]azepine-5-carbonylchloride;1,3-Benzenediacetonitrile,a,a,a',a'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)- (9CI);2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile);2-[3-(2-Cyano-2-propyl)-5-(1,2,4-triazol-1-ylmethyl)phenyl]-2-methylpropiononitrile;Asiolex;Anastrol;Tetramethyl-5-(1H-1,2,4-triazol-1ylmethyl) 1,3-benzenediacetionitrile;
The chemical formula of Anastrozole is C17H19N5 which containing 17 Carbon atoms,19 Hydrogen atoms and 5 Nitrogen atoms,and the molecular weight of Anastrozole is 293.371.
Anastrozole entered its first market in the United Kingdom for the treatment of advanced breast cancer in post-menopausal women. Anastrozole is a highly potent and selective aromatase inhibitor. It is extremely potent in lowering circulating estradiol to undetectable levels in treated patients without altering other circulating hormones. The drug is reportedly well absorbed and tolerated following oral administration.
InChI:InChI=1S/C17H19N5/c1-16(2,9-18)14-5-13(8-22-12-20-11-21-22)6-15(7-14)17(3,4)10-19/h5-7,11-12H,8H2,1-4H3
Relevant articles related to Anastrozole:
|
Article |
Source |
|
A process for synthesizing preparing anastrozole |
- Paragraph 0014; 0017-0018, (2017/01/23) |
|
A method of synthesis of aromatase inhibitors |
- Paragraph 0036-0038, (2017/02/24) |
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