CasNo: 23111-00-4
Molecular Formula: C11H15ClN2O5
NR+ is a highly effective vitamin B3 typ...
The invention belongs to the technical f...
The invention discloses a synthesis meth...
The invention provides an intermediate s...
5’,3‘,2’-tri-O-acetyl-1-β-D-ribofuranosylnicotinamide chloride
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)
Conditions | Yield |
---|---|
With
ammonia;
In
methanol;
at -3 ℃;
for 24h;
Temperature;
|
89.3% |
With
ammonia;
In
methanol;
at -15 - -10 ℃;
Temperature;
Reagent/catalyst;
|
82% |
With
ethanol; ammonia;
at 10 - 20 ℃;
for 3h;
|
78% |
With
methanol; ammonia;
at -5 - 0 ℃;
for 12h;
Large scale;
|
78% |
With
hydrogenchloride;
In
methanol; ethanol;
at 20 ℃;
for 4h;
|
64% |
With
ammonia;
In
methanol;
at 0 ℃;
for 14h;
Large scale;
|
60% |
With
methanol; ammonia;
|
|
With
hydrogenchloride;
In
methanol;
for 12h;
Reagent/catalyst;
Solvent;
Sealed tube;
|
|
With
methanol; propylamine;
at -5 ℃;
for 22h;
Temperature;
|
1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofur-2-yl]-1,4-dihydropyridine-3-carboxamide
3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside)
Conditions | Yield |
---|---|
With
ammonium chloride;
In
water;
at 20 ℃;
for 1h;
Solvent;
|
100% |
With
5%-palladium/activated carbon; ammonium chloride;
In
isopropyl alcohol;
at 20 ℃;
for 20h;
under 1500.15 Torr;
Reagent/catalyst;
Temperature;
Solvent;
Pressure;
Green chemistry;
|
89% |
5’,3‘,2’-tri-O-acetyl-1-β-D-ribofuranosylnicotinamide chloride
3-carbamoyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose
2,3,5-tri-O-acetyl-α-D-ribofuranosyl chloride
nicotinamide mononucleotide
1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofur-2-yl]-1,4-dihydropyridine-3-carboxamide