CasNo： 132112-35-7
Molecular Formula： C17H29ClN2O2
Appearance： white solid
|
Description |
(–)-Ropivacaine is a potent and reversible blocker of sodium channels in nerve fibers. In vivo, (–)-ropivacaine induces complete impairment of proprioception, motor function, and nociception in the hindleg of rats when 100 μL of an 8 mM solution is injected percutaneously into the sciatic nerve. (–)-Ropivacaine depresses myocardial contractile force in isolated rat hearts less potently than (±)-ropivacaine, as well as (–)- and (±)-bupivacaine . Formulations containing (–)-ropivacaine have been used as local anesthetics during surgery and childbirth. |
|
Chemical Properties |
White Solid |
|
Uses |
Anesthetic (local) |
|
Definition |
ChEBI: The monohydrate form of (S)-ropivacaine hydrochloride. |
|
General Description |
Ropivacaine has lidocaine-related structure with tertiary amine side chains.?It is a pure S(-)enantiomer with a propyl group on the piperidine nitrogen atom. |
|
Biochem/physiol Actions |
Local anaesthetic with less cardiotoxicity than bupivacaine; causes reversible blockade of impulse propagation along nerve fibres by preventing the inward movement of sodium ions through the cell membrane of the nerve fibers. |
InChI:InChI=1/C17H26N2O.ClH.H2O/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;;/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H;1H2
The present invention describes a novel ...
New process for the preparation of ropiv...
ropivacaine
ropivacaine hydrochloride monohydrate
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; water;
In
acetone;
pH=2;
Product distribution / selectivity;
Heating / reflux;
|
82% |
|
With
hydrogenchloride; water;
at 0 - 85 ℃;
for 48h;
Product distribution / selectivity;
|
79% |
ropivacaine hydrochloride
ropivacaine hydrochloride monohydrate
| Conditions | Yield |
|---|---|
|
With
water;
at 40 ℃;
for 20h;
Product distribution / selectivity;
|
ropivacaine hydrochloride
ropivacaine