CasNo： 1379686-30-2
Molecular Formula： C20H24ClN3O4S
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SR9009 is , while it's Molecular Formula is C20H24ClN3O4S. SR 9009 is a synthetic REV-ERB agonist that regulates circadian behavior and metabolism; has potential use in the treatment of sleep disorders and metabolic diseases. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.
The CAS number of SR9009 is 1379686-30-2.
More information of SR9009 1379686-30-2 are:
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Synonyms |
SR9009;3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester |
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CAS Number |
1379686-30-2 |
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Molecular Formula |
C20H24ClN3O4S |
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Molecular Weight |
437.947 |
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Density |
1.327±0.06 g/cm3(Predicted) |
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Boiling Point |
547.2±45.0 °C(Predicted) |
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PSA |
106.84000 |
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LogP |
5.25140 |
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Pka |
6.12±0.50(Predicted) |
SR-9009 is an agonist at nuclear receptor Rev-ErbA. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model. SR-9009 suppresses atherosclerosis in a mouse model. Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues. Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.
Articles related to SR9009:
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Article |
Source |
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Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα |
Shin, Youseung,Noel, Romain,Banerjee, Subhashis,Kojetin, Douglas,Song, Xinyi,He, Yuanjun,Lin, Li,Cameron, Michael D.,Burris, Thomas P.,Kamenecka, Theodore M. , p. 4413 - 4417 (2012/07/17) |
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