CasNo: 1722-62-9
Molecular Formula: C15H22N2O.HCl
Appearance: White or off white crystalline powder
Chemical Properties |
White Solid |
Uses |
Mepivacaine HCl, is a local anesthetic widely utilized in the United States for its pain-relieving properties. It is primarily administered by healthcare professionals, particularly in dentistry and minor surgical procedures, to provide temporary and localized anesthesia by blocking nerve signals in the targeted area. It is generally considered safe when used as directed by healthcare professionals in the United States. |
Definition |
ChEBI: The hydrochloride salt of mepivacaine. It is used as a local anaesthetic. |
Brand name |
Arestocaine Hydrochloride (Solvay Pharmaceuticals); Carbocaine (Hospira); Isocaine Hydrochloride(Novocol); Polocaine (AstraZeneca); Polocaine (Dentsply); Scandonest (Deproco). |
Biochem/physiol Actions |
Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems. |
Safety Profile |
skin irritant. Questionable carcinogen with |
InChI:InChI=1/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H
Treatment with TA also induced higher WBC counts and mepivacaine concentrations in synovial fluid, compared with results for mepivacaine alone.
Mepivacaine hydrochloride in combination with LPS caused an increase in empty lacunae and pyknotic nuclei (P < 0.001), which included the deeper cartilage zones. Mepivacaine hydrochloride amplified the negative influence of LPS on chondrocytes.
2-{[(2,6-Dimethylphenyl)amino]carbonyl}-1,1-dimethylpiperidinium iodide