CasNo： 1182367-47-0
Molecular Formula： C20H16ClN5O2
Appearance： A crystalline solid
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RAD140 is A crystalline solid, while it's Molecular Formula is C20H16ClN5O2. RAD140 is a potent, orally bio-available, and non-steroidal selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer.
The CAS number of RAD140 is 1182367-47-0.
More information of RAD140 1182367-47-0 are:
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Synonyms |
2-chloro-4-(((1R,2S)-1-(5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl)-2-hydroxypropyl)amino)-3-methylbenzonitrile;2-chloro-4-[[(1R,2S)-1-[5-(4-cyanophenyl)-1,3,4-oxadiazol-2-yl]-2-hydroxypropyl]amino]-3-methylbenzonitrile;Testolone; |
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CAS Number |
1182367-47-0 |
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Molecular Formula |
C20H16ClN5O2 |
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Molecular Weight |
393.832 |
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Density |
1.41±0.1 g/cm3(Predicted) |
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Boiling Point |
687.7±65.0 °C(Predicted) |
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PSA |
118.76000 |
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LogP |
4.04876 |
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Pka |
13.76±0.20(Predicted) |
RAD140 (also known as Testolone) is an oral nonsteroidal selective androgen receptor modulator (SARM) that cannot be converted to estrogen by aromatase. It has been demonstrated that RAD140 has high AR affinity and target selectivity, showing marked tissue-selective AR agonist activity comparable to natural androgens in breast cancer cells, while lacking agonist activity in prostate cancer cells.We have recently reported anti-tumor activity of RAD140 in multiple in vivo and in vitro models of AR/ER+ breast cancer as a single agent and in combination with inhibitors of CDK4/6 and mTOR.Pharmacodynamic investigation indicates RAD140 acted as an AR agonist in breast cancer cells while suppressing ER signaling and reduced ESR1 mRNA expression.RAD140 exhibited anti-tumor activity in patient-derived xenograft (PDX) models of AR/ER+ breast cancer, as single agent and in combination with inhibitors of CDK4/6 or mTORRAD140 inhibited ER signaling and ESR1 mRNA level in the HBCx-22 PDX model.
Articles related to RAD140:
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Article |
Source |
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Selective androgen receptor modulators |
- Page/Page column 56, (2009/10/18) |
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