What is the (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile?

(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile is , while it's Molecular Formula is C 12 H 13 N 5 O 4 . GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug.

What is the CAS number for (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile?

The CAS number of (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile is 1191237-69-0.

What is (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile (1191237-69-0) used for?

GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production (RNA synthesis arrest), either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection. Remdesivir is used as a treatment for Ebola virus disease and Marburg virus infections and other single stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus and the coronaviruses (including MERS and SARS viruses). Remdesivir is effective in the control of 2019-nCoV (COVID-19) infection in vitro. It now also has been studied as potential treatment of SARS-CoV-2 infections.

What is the (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile?

(2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile is , while it's Molecular Formula is C 12 H 13 N 5 O 4 . GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug.

What is the CAS number for (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile?

The CAS number of (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile is 1191237-69-0.

What is (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile (1191237-69-0) used for?

GS-441524 is the active prodrug of the broad-spectrum antiviral Remdesivir. GS-441524 is an adenosine nucleotide analog in viral RNA production. It is a nucleotide analog inhibitor of RNA-dependent RNA polymerases (RdRps). The compound interferes with the action of viral RNA polymerase and evades proofreading by viral exoribonuclease (ExoN), causing a decrease in viral RNA production (RNA synthesis arrest), either by terminating RNA chains or causing mutations. It inhibits MERS-CoV or SARS-CoV-infected HAE cultures (EC50=74nM and 69nM) and murine hepatitis virus (MHV) (EC50=30nM). In vivo, remdesivir (25 and 50 mg/kg) reduces lung viral titers and prevents weight loss in a mouse model of SARS-CoV infection. Remdesivir is used as a treatment for Ebola virus disease and Marburg virus infections and other single stranded RNA viruses such as respiratory syncytial virus, Junin virus, Lassa fever virus, Nipah virus, Hendra virus and the coronaviruses (including MERS and SARS viruses). Remdesivir is effective in the control of 2019-nCoV (COVID-19) infection in vitro. It now also has been studied as potential treatment of SARS-CoV-2 infections.

High Quality Inosine Safe Shipping GS-441524 1191237-69-0 In Medicine

Product Details;

CasNo： 1191237-69-0

High Quality Inosine Safe Shipping GS-441524 1191237-69-0 In Medicine We supply high quality GS-441524 (CAS 1191237-69-0), in stock, factory directly supply to clients, lower prices, more competitiveness.

What is the GS-441524 ?

GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug.

What is the CAS number for GS-441524 ?

The CAS number of GS-441524 is 1191237-69-0.

More information of GS-441524 1191237-69-0 are:

Synonyms	GS-441524
CAS Number	1191237-69-0
Molecular Formula	C₁₂H₁₃N₅O₄
Molecular Weight	291.266
Density	1.84±0.1 g/cm3(Predicted)
Melting Point	> 233° C (dec.)

What is GS-441524 (1191237-69-0) used for?

GS-441524 is a crucial active prodrug found in Remdesivir, a broad-spectrum antiviral medication. It functions as an adenosine nucleotide analog that interferes with viral RNA production by inhibiting RNA-dependent RNA polymerases (RdRps). This interference leads to a decrease in viral RNA production, making it effective against various viruses, including coronaviruses like MERS and SARS, as well as Ebola, Marburg, and other single-stranded RNA viruses. Remdesivir, which contains GS-441524, has demonstrated efficacy in controlling infections caused by these viruses and is particularly relevant in the context of the ongoing COVID-19 pandemic. While the paragraph also highlights a lack of publicly registered data on the substance's specific uses, manufacture, and environmental release, it underscores the significance of GS-441524 and Remdesivir in antiviral therapies.

Articles related to GS-441524:

Article	Source
Synthesis method of antiviral drug ridexivir and intermediate thereof	- , (2021/02/06)
Current knowledge about the antivirals remdesivir (GS-5734) and GS-441524 as therapeutic options for coronaviruses	One Health Volume 9, June 2020, 100128
Synthesis method of key intermediate of ridecevir	- , (2021/08/07)
Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis	Journal of Feline Medicine and Surgery

How to get the best price on GS-441524?

Hebei Qianglong Technology import and export Co, LTD is a quality supplier and manufacturer of GS-441524 . You can buy high quality, low price GS-441524 1191237-69-0 here. Contact us.

Home

About us

StructureSearch

Products

Pharmaceutical raw material

SARMs

HGH

Inquiry

steroid liquid

Biochemical Engineering

API

Chemical Reagents

Analytical Chemistry

Organic Chemistry

Pharmaceutical intermediates

Flavors and fragrances

Peptides

Diet pills

News

Contact Us

Services

Manufacturing

GS-441524