CasNo: 2152628-33-4
Provided herein is a crystalline form of...
The invention relates to a method for pr...
The invention relates to pyrazolo[1,5-a]...
The invention relates to an RET inhibito...
6-methoxy-3-pyridinecarboxaldehyde
4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile dihydrochloride
6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3.6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
Conditions | Yield |
---|---|
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
|
93% |
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
|
93% |
With
sodium tris(acetoxy)borohydride;
at 20 ℃;
Reagent/catalyst;
|
93% |
With
sodium tris(acetoxy)borohydride; triethylamine;
In
dichloromethane;
at 20 ℃;
|
59% |
6-methoxy-3-pyridinecarboxaldehyde
4-(6-(3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)-6-(2-hydroxy-2-methylpropoxy)pyrazolo[1,5-a]pyridine-3-carbonitrile
6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3.6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile
Conditions | Yield |
---|---|
With
sodium cyanoborohydride; acetic acid;
In
methanol; 1,2-dichloro-ethane;
at 80 ℃;
for 4h;
|
78.8% |
With
sodium tris(acetoxy)borohydride; triethylamine;
In
dichloromethane; dimethyl sulfoxide;
at 20 - 50 ℃;
|
74% |
With
sodium tris(acetoxy)borohydride;
In
1,2-dichloro-ethane;
at 20 ℃;
for 12h;
|
15.4% |
4-bromo-6-hydroxypyrazolo[ 1,5-a]pyridine-3-carbonitrile
6-methoxy-3-pyridinecarboxaldehyde
3-bromo-5-methoxypyridine
6-bromo-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile