• Lorlatinib(PF-06463922)

Lorlatinib(PF-06463922)

  • CasNo：1454846-35-5
  • Purity：99%

Product Details;

CasNo： 1454846-35-5

Factory Sells High Quality Lorlatinib(PF-06463922) 1454846-35-5 best quality

  • Molecular Formula:C21H19FN6O2
  • Molecular Weight:406.419
  • Melting Point:184-187°C 
  • Boiling Point:675.0±55.0 °C(Predicted) 
  • PKA:6.05±0.40(Predicted) 
  • Density:1.42±0.1 g/cm3(Predicted) 

1454846-35-5 Relevant articles

Conformational Studies and Atropisomerism Kinetics of the ALK Clinical Candidate Lorlatinib (PF-06463922) and Desmethyl Congeners

Elleraas, Jeff,Ewanicki, Jason,Johnson, Ted W.,Sach, Neal W.,Collins, Michael R.,Richardson, Paul F.

, p. 3590 - 3595 (2016)

Lorlatinib (PF-06463922) is an ALK/ROS1 ...

Preparation method of anticancer drug

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Paragraph 0028-0047, (2021/03/13)

The invention provides a preparation met...

Application of TBTU in preparation of anti-cancer drug

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Paragraph 0028-0048, (2021/03/11)

The invention provides application of TB...

Preparation method of lorlatinib

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The invention relates to a preparation m...

Preparation method of anti-tumor drug Lorlatinib

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Paragraph 0030; 0040-0044; 0054-0057; 0067-0069, (2021/08/21)

The invention relates to a preparation m...

1454846-35-5 Process route

C<sub>21</sub>H<sub>21</sub>FN<sub>6</sub>O<sub>3</sub>

C21H21FN6O3

(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
1454846-35-5

(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile

Conditions
Conditions Yield
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 50 ℃; for 3h; Temperature; Reagent/catalyst;
89.4%
With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 50 ℃; for 3h; Temperature; Solvent; Reagent/catalyst;
89.4%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; at 65 ℃; for 5h; Green chemistry;
87.6%
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 65 ℃; for 5h;
78.5%
2-[(10R)-3-cyano-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-7-yl]imidodicarbonic acid 1,3-bis(1,1-dimethylethyl) ester

2-[(10R)-3-cyano-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-7-yl]imidodicarbonic acid 1,3-bis(1,1-dimethylethyl) ester

(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
1454846-35-5

(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile

Conditions
Conditions Yield
With hydrogenchloride; In methanol; water; at 60 ℃; for 3h;
82%
With hydrogenchloride; water; In ethyl acetate; at 25 ℃; Inert atmosphere; Large scale;
In tetrahydrofuran; at 225 ℃; for 0.166667h; under 38787.1 Torr; Flow reactor;
With hydrogenchloride; In water; ethyl acetate; at 28 ℃; for 17h; Temperature;
676 mg

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