CasNo: 103-90-2
Molecular Formula: C8H9NO2
Appearance: White crystalline powder
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Acetaminophen (Tylenol) is an effective antipyretic and analgesic that is well tolerated at therapeutic doses. It has only weak antiinflammatory activity; thus, it is not useful in the treatment of rheumatoid arthritis and other inflammatory conditions.
Acetaminophen is widely used as an analgesic and fever-reducing agent. Acetaminophen is designed for moderate analgesia. It is also effective like aspirin and is used in analgesia for headaches (from weak to moderate pain), myalgia, arthralgia, chronic pain, for oncological and post-operational pain, etc.
glutathion
N-acetyl-p-benzoquinoneimine
4-acetaminophenol
S-(5'-Acetamido-2'-hydroxyphenyl)glutathion
Conditions | Yield |
---|---|
In
water; benzene;
at 37 ℃;
Product distribution;
|
4-Hydroxyacetophenone
N-Methyl 4-hydroxy benzamide
4-acetaminophenol
4-hydroxyacetophenone oxime
Conditions | Yield |
---|---|
With
hydroxylamine sulfate;
at 80 ℃;
for 2.5h;
|
85% 15% |
With
hydroxylamine sulfate;
at 80 ℃;
for 2.5h;
|
15% 83% |
The CAS number of 4-Acetamidophenol is 103-90-2.
More information of 4-Acetamidophenol 103-90-2 are:
CAS Number |
103-90-2 |
Density |
1.249 g/cm3 |
Melting Point |
168-172 °C(lit.) |
Boiling Point |
387.8 °C at 760 mmHg |
Flash Point |
188.4 °C |
Vapor Pressure |
0.008Pa at 25℃ |
Refractive Index |
1.5810 (rough estimate) |
HS CODE |
2924.29 |
PSA |
49.33000 |
LogP |
1.42360 |
Pka |
9.86±0.13(Predicted) |
Synonyms for 4-Acetamidophenol 103-90-2:Acetamide,N-(4-hydroxyphenyl)-;Acetanilide,4'-hydroxy- (7CI,8CI);4-(Acetylamino)phenol;4-(N-Acetylamino)phenol;4-Acetamidophenol;4-Acetaminophenol;4-Hydroxyacetanilide;4'-Hydroxyacetanilide;Alpiny;Alvedon;Anhiba;Apamid;Apamide;Banesin;Ben-u-ron;Bickie-mol;Biocetamol;Cetadol;Clixodyne;Daphalgan;Datril;Dirox;Enelfa;Eu-Med;Exdol;Gattaphen T;Homoolan;Jin Gang;Korum;Lestemp;Liquagesic;Lonarid;Lyteca;Lyteca Syrup;Minoset;Minoset Plus;Momentum;Multin;N-(4-Hydroxyphenyl)acetamide;N-Acetyl-4-aminophenol;N-Acetyl-4-hydroxyaniline;Pacemo;Pacemol;Panadol;Panadol Actifast;Panadol Extend;Panaleve;Panasorb;Panets;Panodil;Paracetamol;Paracetamol DC;Paracetamole;Parageniol;Paralen;Paramol;Paraspen;Parelan;Parmol;Pasolind N;Pedric;k*e*t*a*m*i*n*e ,kush available;
The chemical formula of 4-Acetamidophenol is C8H9NO2 which containing 8 Carbon atoms,9 Hydrogen atoms,1 Nitrogen atoms and 2 Oxygen atoms,and the molecular weight of 4-Acetamidophenol is 151.165.
Acetaminophen is an analgesic and antipyretic compound. Unlike many NSAIDs, which inhibit both COX-1 and COX-2, early studies suggested that acetaminophen is a poor inhibitor of both isoforms. However, it does inhibit COX-2 by 83% and COX-1 by 56% in human blood ex vivo, albeit at a high 1,000 mg dose, with IC50 values of 25.8 and 113.7 μM, respectively. Acetaminophen is enzymatically and non-enzymatically converted to several reactive metabolites that contribute to adverse or indirect effects, including liver injury. At toxic doses, the acetaminophen metabolite N-acetyl-4-benzoquinone imine (NAPQI; ) depletes glutathione reserves in the liver, leading to an accumulation of NAPQI and subsequent hepatocyte necrosis. Acetaminophen decreases glutathione levels and reduces glutathione peroxidase activity in mice when administered at a dose of 250 mg/kg and induces ferroptotic cell death in primary mouse hepatocytes, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . Acetaminophen has analgesic and antipyretic properties in animal models.
InChI:InChI=1/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)/i2D,3D,4D,5D
Relevant articles related to 4-Acetamidophenol:
Article |
Source |
Influence of medium and temperature on the hydrolysis kinetics of propacetamol hydrochloride: Determination using derivative spectrophotometry |
Barcia, Emilia,Martin, Alicia,Azuara, Ma. Luz,Negro, Sofia , p. 277 - 280 (2005) |
Subphthalocyanines: Addressing water-solubility, nano-encapsulation and activation for optical imaging of B16 melanoma cells |
Bernhard, Yann,Winckler, Pascale,Chassagnon, Remi,Richard, Philippe,Gigot, lodie,Perrier-Cornet, Jean-Marie,Decrau, Richard A. , p. 13975 - 13978 (2014) |
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