• Pramoxine HCl

Pramoxine HCl

  • CasNo:637-58-1
  • Purity:99%

Product Details;

CasNo: 637-58-1

Molecular Formula: C17H28ClNO3

Appearance: White or off white crystalline powder

Competitve Price Fast Delivery Pramoxine HCl 637-58-1 Good Price

  • Molecular Formula:C17H28ClNO3
  • Molecular Weight:329.867
  • Appearance/Colour:White or off white crystalline powder 
  • Vapor Pressure:1.7E-07mmHg at 25°C 
  • Melting Point:181-183oC 
  • Boiling Point:427 °C at 760 mmHg 
  • Flash Point:123.5 °C 
  • PSA:30.93000 
  • LogP:3.70650 

Pramoxine hydrochloride(Cas 637-58-1) Usage


Pramoxine, also known as pramocaine, is different from other local anesthetic compounds in chemical structure. Active groups which are carboxylic acid derivatives like ester and amide are not present in this molecule. The drug molecule consists of ether functional groups that are much less active on a chemical level. The presence of the free radical morpholine in this compound is the cause of the reduction of the factor of toxicity and pharmacological activity. In pramoxine, toxicity is reduced but the local anesthetic affect is maintained.Pramoxine Hydrochloride is the hydrochloride salt form of pramoxine, It is a common, over-the-counter anti-itch ingredient that provides temporary relief from itching caused by insect bites, minor skin irritations, poison ivy, sunburn and more.


Tronothane, Abbott, US ,1954


muscle relaxant (smooth)


Pramoxine hydrochloride (Itch-X, PrameGel, Prax, Tronothane, AmLactin AP) is a local anesthetic that is structurally similar to dyclonine and unrelated to the esteror amide-type compounds.Apply to affected area t.i.d. to q.i.d., as directed by a physician. Useful for patients sensitive to ester and/or amide anesthetics. Onset of anesthesia is within minutes. Duration of anesthesia is 2 to 4 hours.

Manufacturing Process

About 5.6 g of potassium hydroxide is dissolved in about 150 cc of refluxing ethanol, and then about 16.6 g of hydroquinone monobutyl ether is added to the alcoholic solution. When the hydroquinone is dissolved, about 16.3 g of γmorpholinopropyl chloride (dissolved in a small amount of ethanol) is added to the refluxing solution. The solution is refluxed for about 24 hours and then cooled. The product is recovered by filtering the reaction mixture and then removing the solvent by vacuum distillation. The oily residue is acidified and shaken with ether. The acidic phase is made strongly alkaline with 40% sodium hydroxide, and the oil which separates is extracted into ether. The ethereal phase is dried, and the solvent removed by vacuum distillation. The product distills at 183° to 184°C at a pressure of 2.8 mm. The hydrochloride salt of the foregoing base is prepared by dissolving the base in ether and acidifying with hydrochloric acid and is found to have a MP of 181° to 183°C.

Brand name

Tronolane (Ross); Tronothane (Abbott).

Therapeutic Function

Local anesthetic

Clinical Use

Pramoxine is an amino-ether which, like dyclonine, is used as a topical agent in the form of its hydrochloride. Pramoxine hydrochloride may be used for anaesthesia of minor skin wounds and the relief of haemomhoids and other anorectal disorders.The drug is an ingredient of many proprietary topical products, and the U.S.P. has official cream and gel formulations.

Veterinary Drugs and Treatments

A surface and local anesthetic to peripheral nerves not related structurally to procaine-type anesthetics, pramoxine is often added to other topicals to reduce pain and/or itching.

Mode of action

Pramoxine hydrochloride is the hydrochloride salt form of pramoxine, a morpholine derivative with local anesthetic property. Pramocaine hydrochloride decreases the permeability of the neuronal membrane to sodium ions by reversibly binding to and inhibiting voltage-gated sodium channels. This results in stabilization of the membrane and, thereby inhibiting the ionic fluxes required for membrane depolarization, hence resulting in the failure to initiate a propagated action potential and subsequent conduction blockade.


637-58-1 Relevant articles

A pramoxine hydrochloride preparing method


Paragraph 0019; 0021, (2018/04/21)

The invention belongs to the technical f...

637-58-1 Process route





pramoxine hydrochloride

pramoxine hydrochloride

Conditions Yield
With sodium hydride; In tetrahydrofuran; at 20 ℃; for 5h; Reflux;

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