CasNo： 855-19-6
Molecular Formula： C21H29ClO3
|
Originator |
Clostebol acetate,Hunan Steroid |
|
Uses |
Clostebol acetate is an anabolic steroid. This is a controlled substance. |
|
Manufacturing Process |
15 g of a mixture of 4β,5-epoxy-etiocholane-17β-ol-3-one and 4β,5-epoxyandrostane-17β-ol-3-one, dissolved in 375 ml chloroform, are treated with a stream of gaseous HCl at room temperature for about 2 h. The chloroform solution is neutralized with a sodium bicarbonate solution, washed with water and dried. The residue is crystallized from benzene or aqueous methanol and 9 g of needle-shaped crystals of 4-chloro-testosterone, melting point 186°- 188°C, are obtained. Upon concentrating the mother-liquor, 3.2 g of thisproduct, melting point 180°-184°C, are covered. 1 g 4-chloro-testosterone are acetylated with 1 ml acetic anhydride and 5 ml pyridine at room temperature for 16 h. Ice is added to the solution, and the precipitate is filtered off and recrystallized from chloroform-ethanol; 1 g 4- chloro-testosterone-acetate, melting point 228°-230°C, is obtained. |
|
Therapeutic Function |
Anabolic |
|
Hazard |
A poison by ingestion. A reproductive hazard. |
InChI:InChI=1/C21H29ClO3/c1-12(23)25-18-7-6-14-13-4-5-16-19(22)17(24)9-11-20(16,2)15(13)8-10-21(14,18)3/h13-15,18H,4-11H2,1-3H3/t13-,14-,15-,18-,20+,21-/m0/s1
-
A simple one pot procedure flor the sele...
The use of Cp2YCl and YCl3 as effective ...
The chlorination of a number of androst-...
-
testosterone acetate
clostebol acetate
| Conditions | Yield |
|---|---|
|
testosterone acetate;
With
3,3-dimethyldioxirane;
In
acetone;
at 20 ℃;
for 8h;
With
Amberlyst 15; sodium chloride;
In
acetone;
at 20 ℃;
for 12h;
|
89% |
|
With
pyridine; sulfuryl dichloride;
for 1h;
Product distribution;
Ambient temperature;
other steroids;
|
|
|
With
pyridine; sulfuryl dichloride;
for 1h;
Ambient temperature;
|
|
|
Multi-step reaction with 2 steps
1: N-chloro-succinimide, HN3 / CHCl3; 2-methyl-propan-2-ol
2: SiO2 / benzene
With
N-chloro-succinimide; tris-(2-chloro-ethyl)-amine; silica gel;
In
chloroform; tert-butyl alcohol; benzene;
|
|
|
Multi-step reaction with 2 steps
1: N-chloro-succinimide, HN3 / CHCl3; 2-methyl-propan-2-ol
2: SiO2 / benzene
With
N-chloro-succinimide; tris-(2-chloro-ethyl)-amine; silica gel;
In
chloroform; tert-butyl alcohol; benzene;
|
17β-acetoxy-4β,5β-epoxyandrostan-3-one
clostebol acetate
| Conditions | Yield |
|---|---|
|
With
hydrogenchloride; acetic acid;
|
17β-acetoxy-4β,5β-epoxyandrostan-3-one
testosterone acetate
acetic anhydride
4β-Chlor-5β-azido-androstanol-17β-on-3-acetat
6-dehydrotestosterone
androsta-4,6-dien-17β-ol-3-one acetate
clostebol
17β-acetoxyandrost-1,4,6-trien-3-one